5 Benefits of Premarin
![A woman holding a glass of water and a Premarin pill in hand](https://images.medicinenet.com/images/article/main_image/medicine-pill-water.jpg?output-quality=75)
Premarin (conjugated estrogens) is a form of hormone replacement therapy (HRT) that is a mixture of several different estrogens derived from natural sources. It is available as a tablet and a cream.
The benefits of taking Premarin include:
- Relief of vaginal symptoms due to menopause
- Vaginal dryness
- Inflammation
- Painful intercourse due to atrophy of the vagina and vulva
- Hot flashes
- Night sweats
- Helps prevent thinning of the bones (osteoporosis), which can cause fractures
- Also used to treat women where either the ovaries do not function properly or have been removed
What Are Side Effects of Premarin?
Common side effects of Premarin (conjugated estrogens) may include:
- Breakthrough bleeding or spotting
- Excessively prolonged periods
- Loss of periods
- Breast pain
- Breast enlargement
- Changes in sex drive
Serious side effects of Premarin may include:
- Gallstones
- Hepatitis
- Migraine headaches
- Fluid retention (swelling of the lower legs)
- Tan or brown patches of skin on the forehead, cheeks, or temples (melasma)
- Increased risk of breast cancer, blood clots, and stroke
- Increased risk of impaired cognition and/or dementia among women over age 65
- Increase in the curvature of the cornea, which can cause intolerance to contact lenses
What Are Drug Interactions of Premarin?
Premarin (conjugated estrogens) may interact with:
- Rifampin
- Barbiturates
- Phenytoin
- Carbamazepine
- Griseofulvin
- St. John's wort
- Primidone
- Erythromycin
- Clarithromycin
- Ketoconazole
- Itraconazole
- Ritonavir
- Thyroid replacement therapy
- Corticosteroids, such as dexamethasone
- Cyclosporine
- Grapefruit juice
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Reviewed on 12/2/2022
References
Image source: iStock Images
https://www.medicinenet.com/conjugated_estrogens_vaginal_cream/article.htm
https://www.medsafe.govt.nz/Consumers/cmi/p/premarin.pdf
https://www.medicinenet.com/conjugated_estrogens_vaginal_cream/article.htm
https://www.medsafe.govt.nz/Consumers/cmi/p/premarin.pdf